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Side effects of LHRH analogs

Most side effects of LHRH analogs are similar to those experienced after orchiectomy and result from the dramatic reduction in the body’s testosterone.

  1. * Diminished libido (sexual desire) occurs in 90 percent of men undergoing hormone therapy.

  2. * Erectile dysfunction (inability to achieve or maintain an erection adequate for intercourse) occurs in 90 percent of men undergoing hormone therapy.

  3. * Hot flashes are similar to those experienced by women during menopause. They are characterized by a sudden spread of warmth to the face, neck and upper torso, usually followed by profuse sweating. Although uncomfortable, hot flashes pose no health risk. Their effects may be controlled with medication.

  4. * Weight gain of 10 to 15 pounds is a common occurrence.

  5. * Mood swings are common with hormone therapy.

  6. * Depression may occur with hormone therapy. It may be attributed to a variety of causes, including the treatment itself, reaction to side effects, or other cancer-related issues. Symptoms of depression include feelings of hopelessness, loss of interest in usually enjoyable activities, inability to concentrate and changes in appetite and sleeping patterns. Men experiencing depression are advised to speak to their physician or other member of their health care team about available resources for depression.

  7. * Fatigue is a feeling of extreme tiredness that may not be alleviated by rest or sleep. It is caused by decreased testosterone production.

  8. * Anemia is a deficiency of red blood cells in the bloodstream, resulting in reduced oxygen to tissues and organs and feelings of tiredness or weakness. Anemia can be treated with medications, vitamins and minerals.

  9. * Loss of muscle mass may manifest as decreased strength or weakness. A careful exercise program with progressive weight-bearing activities will improve strength.

  10. * Osteoporosis, a long-term effect of hormone therapy is a loss of bone mineral density where the bones become thinner, more brittle and at increased risk for breaking. It is the same condition experienced by women in menopause. Osteoporosis can be treated with medications, calcium and vitamin D. An exercise program with progressive weight-bearing activities will also help strengthen bones.

    information last updated on October, 2006

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